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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
ALDH18A1
All Species:
24.55
Human Site:
S274
Identified Species:
38.57
UniProt:
P54886
Number Species:
14
Phosphosite Substitution
Charge Score:
-0.07
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P54886
NP_001017423.1
795
87302
S274
D
V
E
G
L
F
D
S
P
P
G
S
D
D
A
Chimpanzee
Pan troglodytes
XP_001155890
796
87730
S275
D
V
E
G
L
F
D
S
P
P
G
S
D
D
A
Rhesus Macaque
Macaca mulatta
XP_001099359
795
87154
S274
D
V
E
G
L
F
D
S
P
P
G
S
D
D
A
Dog
Lupus familis
XP_534976
795
87233
S274
D
V
E
G
L
F
D
S
P
P
G
S
D
D
A
Cat
Felis silvestris
Mouse
Mus musculus
Q9Z110
795
87278
S274
D
V
E
G
L
F
D
S
P
P
G
S
D
D
A
Rat
Rattus norvegicus
NP_001101994
795
87311
S274
D
V
E
G
L
F
D
S
P
P
G
S
D
D
A
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001508419
607
66410
N141
G
T
S
V
V
I
A
N
G
T
H
P
K
I
S
Chicken
Gallus gallus
Frog
Xenopus laevis
NP_001086040
815
89190
P275
E
G
L
F
N
S
P
P
G
S
D
D
A
K
L
Zebra Danio
Brachydanio rerio
NP_001077015
782
85358
D260
D
S
P
P
G
S
D
D
A
K
L
L
D
T
F
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_649375
776
84074
K261
D
V
D
G
I
Y
N
K
P
P
W
E
D
G
A
Honey Bee
Apis mellifera
XP_396399
732
79216
L259
D
A
K
V
N
A
A
L
W
A
L
D
R
G
V
Nematode Worm
Caenorhab. elegans
P54889
800
86509
R276
P
P
D
L
E
G
S
R
L
L
Y
T
Y
V
P
Sea Urchin
Strong. purpuratus
XP_781524
752
81324
G259
G
T
S
R
V
G
L
G
G
M
E
S
K
V
K
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
P54888
726
78853
S260
G
V
P
V
I
I
T
S
G
Y
A
A
E
N
I
Baker's Yeast
Sacchar. cerevisiae
P54885
456
49722
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
92.9
97.4
97.1
N.A.
95.3
95.2
N.A.
71.6
N.A.
84.4
82.1
N.A.
55.9
54.7
52.5
56.4
Protein Similarity:
100
94.9
98.2
98.6
N.A.
97.7
97.4
N.A.
74.9
N.A.
90.8
91.5
N.A.
70.8
69.5
69.5
73.3
P-Site Identity:
100
100
100
100
N.A.
100
100
N.A.
0
N.A.
0
20
N.A.
46.6
6.6
0
6.6
P-Site Similarity:
100
100
100
100
N.A.
100
100
N.A.
20
N.A.
6.6
20
N.A.
73.3
13.3
13.3
13.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
44.6
22.8
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
62.1
38.8
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
13.3
0
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
40
0
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
7
0
0
0
7
14
0
7
7
7
7
7
0
47
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
60
0
14
0
0
0
47
7
0
0
7
14
54
40
0
% D
% Glu:
7
0
40
0
7
0
0
0
0
0
7
7
7
0
0
% E
% Phe:
0
0
0
7
0
40
0
0
0
0
0
0
0
0
7
% F
% Gly:
20
7
0
47
7
14
0
7
27
0
40
0
0
14
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
7
0
0
0
0
% H
% Ile:
0
0
0
0
14
14
0
0
0
0
0
0
0
7
7
% I
% Lys:
0
0
7
0
0
0
0
7
0
7
0
0
14
7
7
% K
% Leu:
0
0
7
7
40
0
7
7
7
7
14
7
0
0
7
% L
% Met:
0
0
0
0
0
0
0
0
0
7
0
0
0
0
0
% M
% Asn:
0
0
0
0
14
0
7
7
0
0
0
0
0
7
0
% N
% Pro:
7
7
14
7
0
0
7
7
47
47
0
7
0
0
7
% P
% Gln:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Q
% Arg:
0
0
0
7
0
0
0
7
0
0
0
0
7
0
0
% R
% Ser:
0
7
14
0
0
14
7
47
0
7
0
47
0
0
7
% S
% Thr:
0
14
0
0
0
0
7
0
0
7
0
7
0
7
0
% T
% Val:
0
54
0
20
14
0
0
0
0
0
0
0
0
14
7
% V
% Trp:
0
0
0
0
0
0
0
0
7
0
7
0
0
0
0
% W
% Tyr:
0
0
0
0
0
7
0
0
0
7
7
0
7
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _